标题：AKTIVITAS ANTIINFLAMASI EKSTRAK ETER KULIT BATANG TENGGULUN (Protium javanicum Burm) TERHADAP EDEMA PADA TIKUS WISTAR YANG DIINDUKSI DENGAN KARAGENAN
期刊名称：E-Jurnal Ekonomi dan Bisnis Universitas Udayana
出版年度：2015
卷号：9
期号：1
语种：English
出版社：E-Jurnal Ekonomi dan Bisnis Universitas Udayana
摘要：Stem bark of Tenggulun (Protium javanicum, Burm) has been used traditionally by Balinese people as anti-inflammatory agents. This research aimed to analyze phytochemical contents and to evaluate anti-inflammatory activity of stem bark ether extract of Tenggulun. Phytochemical study was done qualitatively using phytochemical reagents. Anti-inflammatory activity was evaluated on edema rats induced by carrageenan with given extract at doses of 125, 250, and 500 mg/kg b.w. Diclophenac sodium was used as the positive control. Phytochemical study revealed that the stem bark ether extracts consisted of alkaloids, steroids, terpenoids, and phenolic compounds. Anti-inflammatory activity test results showed at a dose of 125 mg/kg b.w, the extract only inhibit inflammation by 34.54%, while a dose of 250 mg/kg b.w gave inhibition of inflammation by 94.34%, and a dose of 500 mg/kg b.w can inhibit inflammation by 96.11% during 360 minutes observation. Probit analysis gave ED50 value of 103.252 mg/kg B.W.
关键词：Anti-inflammatory activity; stem bark of Tenggulun
