摘要：Acinetobacter pittii 44551 was recovered from a patient with gout combined with tuberculosis and was found to harbor the carbapenemase genes bla NDM-1 and bla OXA-58 on two different plasmids pNDM-44551 and pOXA58-44551, respectively. pNDM-44551 displayed high self-transferability across multiple bacterial species, while pOXA58-44551 was likely co-transferable with pNDM-44551 into A. baumannii receipts. pNDM-44551 was a close variant of the previously characterized pNDM-BJ01, and the bla NDM-1 gene cluster was arranged sequentially as orfA , IS Aba14 , aphA6 , IS Aba125 , bla NDM-1, ble MBL, ΔtrpF , dsbC , tnpR , and zeta . pOXA58-44551 was a repAci9-containing plasmid, and bla OXA-58 was embedded in a 372F -IS Aba3 -like- bla OXA-58-IS Aba3 structure. The mobile genetic platforms of bla NDM-1 and bla OXA-58 herein showed some differences from their previously characterized variants. The production of NDM-1 in strain 44551 contributed the majority to its high resistance to carbapenems, while the bla OXA-58 stayed silent most likely due to the lack of an upstream promoter to drive its transcription. Increased surveillance of Acinetobacter co-harboring bla NDM-1 (active) and bla OXA-58 (either active or silent) is urgently needed.
