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  • 标题:The Role of Gluten in Celiac Disease and Type 1 Diabetes
  • 本地全文:下载
  • 作者:Gloria Serena
  • 期刊名称:Nutrients
  • 电子版ISSN:2072-6643
  • 出版年度:2015
  • 卷号:7
  • 期号:9
  • 页码:7143-7162
  • DOI:10.3390/nu7095329
  • 语种:English
  • 出版社:MDPI Publishing
  • 摘要:Celiac disease (CD) and type 1 diabetes (T1D) are autoimmune conditions in which dietary gluten has been proven or suggested to play a pathogenic role. In CD; gluten is established as the instigator of autoimmunity; the autoimmune process is halted by removing gluten from the diet; which allows for resolution of celiac autoimmune enteropathy and subsequent normalization of serological markers of the disease. However; an analogous causative agent has not yet been identified for T1D. Nevertheless; the role of dietary gluten in development of T1D and the potentially beneficial effect of removing gluten from the diet of patients with T1D are still debated. In this review; we discuss the comorbid occurrence of CD and T1D and explore current evidences for the specific role of gluten in both conditions; specifically focusing on current evidence on the effect of gluten on the immune system and the gut microbiota.
  • 关键词:celiac disease; type 1 diabetes; gluten celiac disease ; type 1 diabetes ; gluten
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