文章基本信息
- 标题：Oxidative DNA damage is involved in cigarette smoke-induced lung injury in rats
- 本地全文：下载
- 作者：Zhihai Chen ; Dapeng Wang ; Xing Liu 等
- 期刊名称：Environmental Health and Preventive Medicine
- 印刷版ISSN：1342-078X
- 电子版ISSN：1347-4715
- 出版年度：2015
- 卷号：20
- 期号：5
- 页码：318-324
- DOI：10.1007/s12199-015-0469-z
- 语种：English
- 出版社：Springer Japan
- 摘要：Objective
Reactive oxygen species (ROS) induced by exogenous toxicants are suggested to be involved in carcinogenesis by oxidative modification of DNA. 8-Hydroxyl-2-deoxyguanosine (8-OHdG) has been considered as a reliable biomarker for oxidative DNA damage both in vivo and in vitro studies. But the effect of smoking on oxidative damage has not yet been fully elucidated.
- 关键词：Cigarette smoke ;Rats ;8-Hydroxy-deoxyguanosine ;Reactive oxygen species ;Oxidative stress
