The aim of this study was to evaluate the status of health mangers’ evidence-based decision-making in Kermanshah University of Medial Sciences in 2013. In this descriptive-analytical survey, research tool was a 33-item questionnaire based on Kansas standard. The study sample was randomly drawn from among 180 experts, heads and deputies of health care centers in Kermanshah province. The collected data were analyzed deductively by SPSS 16. There was a significant difference between the number of times evidence-based decision making was used based on gender (P<0.023). However, no difference was observed in terms of management levels (P>0.495). As a result, decision-making based on evidence has been accepted as a new reliable approach among medical staff of Kermanshah university of medical sciences and considered to improve the quality of evidence-based decision-making.