Zoonotic cutaneous leishmaniasis (ZCL) is an increasing and important public health problem in Iran . The use of repellents is recommended as one of the important means of personal protection against vectors of ZCL. This paper reports the repellency effect of the plant Myrtle, Myrtus communis (Myrtaceae), essential oil for protection against 3-7-day-old unfed females of the sandfly, Phlebotomus papatasi Scopoli for the first time in Iran . The tests were carried out under laboratory conditions, using dose-response testing procedure on white rabbits and the results were compared with commonly used repellent, diethyl-3-methylbenzamid (DEET). The modified Wirtz method using K & D apparatus was employed. Effective Dose (EDs) values were estimated from the probit regression line. ED50 was measured as 0.1140 and 0.0006 mg/cm2 for Myrtle essential oil and DEET, respectively. The laboratory tests showed that both Myrtle essential oil and DEET had repellency effects against P.papatasi. In addition, the insecticidal action of Myrtle oil was also observed. We concluded that the two repellents could be used as a mean of personal protection against sand flies.