Dear Editor-in-Chief: Fluoride (F), a powerful oxidizing agent, is used in a variety of industries in China. Health problems among industrial workers due to F poisoning are on the rise. Long-term F exposure, together with varieties of relevant factors, leads to high F burden [blood fluoride (BF), urinary fluoride (UF)], which can finally result in F bone injury (1). As F burden is the major cause of F bone injury, to prevent the F bone injury, we have to control the F burden to a moderate level. The purpose of the present study was to examine the F burden and relevant factors of aluminum plant workers, and provide the basis for the early prevention of F bone injury.