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  • 标题:EFFECT OF VITAMINS A, E, C AND OMEGA-3 FATTY ACIDS ON LIPID PEROXIDATION IN STREPTOZOTOCIN INDUCED DIABETIC RATS
  • 本地全文:下载
  • 作者:FAKHER SH. ; JALALI M. ; TABEI S.M.B.
  • 期刊名称:Iranian Journal of Public Health
  • 印刷版ISSN:2251-6085
  • 电子版ISSN:2251-6093
  • 出版年度:2007
  • 卷号:36
  • 期号:2
  • 页码:58-63
  • 语种:English
  • 出版社:THE SCHOOL OF PUBLIC HEALTH, TEHRAN UNIVERSITY OF MEDICAL SCIENCES
  • 摘要:

    Background: To assess the effect of supplementation with vitamins A, E and C and w -3 fatty acids on lipid peroxidation in streptozotocin (STZ) induced diabetic rats.
    Methods: Sixty four male wistar rats weighting 250g were divided into four groups as normal control, diabetic control, diabetic with vitamin A, E as well as C supplementation and diabetic with w -3 fatty acids supplementation. After four weeks of treatment the rats were anesthetized and malondialdehyde (MDA) levels were investigated in blood samples, liver and heart homogenate.
    Results: In diabetic 3.0rats MDA level in plasma, liver and heart was significantly more elevated than normal control rats (P<0.05). Vitamin A, E and C supplementation caused significant decrease in plasma, liver and heart MDA (P<0.05). A significant decrease in heart MDA (P< 0.05) was observed in diabetic rats with w -3 fatty acids supplementation.
    Conclusion: Supplementation of vitamin A, E and C and w -3 fatty acids was found to decrease lipid peroxidation to some extent in diabetic rats and they can be valuable candidates in the treatment of the complications of diabetes.

  • 关键词:VITAMIN C; VITAMIN E; VITAMIN A; OMEGA3 FATTY ACID; MALONDIALDEHYDE
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