Background: To assess the effect of supplementation with vitamins A, E and C and w -3 fatty acids on lipid peroxidation in streptozotocin (STZ) induced diabetic rats.
Methods: Sixty four male wistar rats weighting 250g were divided into four groups as normal control, diabetic control, diabetic with vitamin A, E as well as C supplementation and diabetic with w -3 fatty acids supplementation. After four weeks of treatment the rats were anesthetized and malondialdehyde (MDA) levels were investigated in blood samples, liver and heart homogenate.
Results: In diabetic 3.0rats MDA level in plasma, liver and heart was significantly more elevated than normal control rats (P<0.05). Vitamin A, E and C supplementation caused significant decrease in plasma, liver and heart MDA (P<0.05). A significant decrease in heart MDA (P< 0.05) was observed in diabetic rats with w -3 fatty acids supplementation.
Conclusion: Supplementation of vitamin A, E and C and w -3 fatty acids was found to decrease lipid peroxidation to some extent in diabetic rats and they can be valuable candidates in the treatment of the complications of diabetes.