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  • 标题:SERUM LEVEL OF ADIPONECTIN AND ITS ASSOCIATION WITH INSULIN SENSITIVITY IN OVERWEIGHT DIABETIC AND NON-DIABETIC IRANIAN MEN
  • 本地全文:下载
  • 作者:GIAHI L. ; JAZAYERI A. ; RAHIMI A.
  • 期刊名称:Iranian Journal of Public Health
  • 印刷版ISSN:2251-6085
  • 电子版ISSN:2251-6093
  • 出版年度:2008
  • 卷号:37
  • 期号:2
  • 页码:88-92
  • 语种:English
  • 出版社:THE SCHOOL OF PUBLIC HEALTH, TEHRAN UNIVERSITY OF MEDICAL SCIENCES
  • 摘要:

    Background: Adiponectin is a protein produced exclusively by adipose tissue; the reduced level of which has been shown to be involved in a variety of obesity-related disorders, such as insulin resistance and diabetes, in different ethnic groups.
    This cross-sectional study was conducted to determine adiponectin level and its association with insulin sensitivity in 20 adult overweight type-2 diabetic and 20 healthy over-weight non-diabetic Iranian men for the first time.
    Methods: Body fat mass (Bio-electric impedance), serum level of adiponectin (ELISA), fasting blood sugar and fasting insulin were measured. Insulin sensitivity was calculated using QUICKI.
    Results: As expected, the mean adiponectin concentration was lower in diabetics (7.7 ± 3 m g/ml) than non-diabetics (8.1 ± 2 m g/ml); however, the difference did not achieve statistical significance (P= 0.5). Adiponectin negatively correlated with fat mass. This correlation was stronger in diabetics with a higher fat mass (r= -0.3 in diabetics vs. r= -0.01 in non-diabetics; p: N.S.). Adiponectin positively related with insulin sensitivity in both groups, although this relation was only statistically significant in non-diabetics (r= +0.5; P= 0.04). The relation between insulin sensitivity and mean of adiponectin level was marginally significant even after adjustment for group (diabetic and non-diabetic), age and fat mass.
    Conclusion: Our findings are consistent with the studies on different ethnic groups which have indicated lower adiponectin levels in diabetics. Also our results confirm the relationship between a low adiponectin level and insulin sensitivity reported in earlier studies.

  • 关键词:ADIPONECTIN; INSULIN SENSITIVITY; OVER-WEIGHT; DIABETES; IRAN
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