摘要：Oseltamivir is used for the treatment of AH1N1 swine influenza in Mexico. The aim of the present study was to analyze the effect of oseltamivir on dopamine levels in patients ex-posed to vitamins A, D, and C as well as to ozone. For this, forty male Wistar rats (80 g) were divided into 6 groups. A combination of oseltamivir (20 vmg/kg) with A (39 v0UI.), C (30 mg) and D (60 UI.) vitamins with or without ozone 0.5 ppm were intraperitoneally administered for 5 days. The exposition to ozone was through a camera controlled. The animals were sacrificed and the brain dissected in cortex (I), hemispheres (II) and cerebellum/medulla oblongata (III) to measure dopamine, glutathione (GSH) and lipoperoxidation using fluo-rescence. Dopamine increased in I, II and III regions while GSH increased only in II and III regions and lipoperoxidation decreased in the same regions. This changes were significant (p < 0.05) in the groups that received oseltamivir and ozone. Administration of oseltamivir and ozone induces synergic effect on dopamine metabolism.
其他摘要：Oseltamivir is used for the treatment of AH1N1 swine influenza in Mexico. The aim of the present study was to analyze the effect of oseltamivir on dopamine levels in patients ex-posed to vitamins A, D, and C as well as to ozone. For this, forty male Wistar rats (80 g) were divided into 6 groups. A combination of oseltamivir (20 vmg/kg) with A (39 v0UI.), C (30 mg) and D (60 UI.) vitamins with or without ozone 0.5 ppm were intraperitoneally administered for 5 days. The exposition to ozone was through a camera controlled. The animals were sacrificed and the brain dissected in cortex (I), hemispheres (II) and cerebellum/medulla oblongata (III) to measure dopamine, glutathione (GSH) and lipoperoxidation using fluo-rescence. Dopamine increased in I, II and III regions while GSH increased only in II and III regions and lipoperoxidation decreased in the same regions. This changes were significant (p < 0.05) in the groups that received oseltamivir and ozone. Administration of oseltamivir and ozone induces synergic effect on dopamine metabolism.
