摘要：Individual cancer susceptibility seems to be related to factors such as changes inoncogenes and tumor suppressor genes expression, and differences in the action ofmetabolic enzymes and DNA repair regulated by specific genes. Epidemiologicalstudies on genetic polymorphisms of human xenobiotics metabolizing enzymes andcancer have revealed low relative risks. Research considering genetic polymorphismsprevalence jointly with environmental exposures could be relevant for a betterunderstanding of cancer etiology and the mechanisms of carcinogenesis and alsofor new insights on cancer prognosis. This study reviews the approaches of molecularepidemiology in cancer research, stressing case-control and cohort designs involvinggenetic polymorphisms, and factors that could introduce bias and confounding inthese studies. Similarly to classical epidemiological research, genetic polymorphismsrequires considering aspects of precision and accuracy in the study design.
其他摘要：Individual cancer susceptibility seems to be related to factors such as changes inoncogenes and tumor suppressor genes expression, and differences in the action ofmetabolic enzymes and DNA repair regulated by specific genes. Epidemiologicalstudies on genetic polymorphisms of human xenobiotics metabolizing enzymes andcancer have revealed low relative risks. Research considering genetic polymorphismsprevalence jointly with environmental exposures could be relevant for a betterunderstanding of cancer etiology and the mechanisms of carcinogenesis and alsofor new insights on cancer prognosis. This study reviews the approaches of molecularepidemiology in cancer research, stressing case-control and cohort designs involvinggenetic polymorphisms, and factors that could introduce bias and confounding inthese studies. Similarly to classical epidemiological research, genetic polymorphismsrequires considering aspects of precision and accuracy in the study design.
