期刊名称：International Journal of Basic & Applied Physiology
印刷版ISSN：2320-172X
出版年度：2013
期号：1453
页码：182-188
出版社：Society of Basic & Applied Physiology
摘要：Background: Electrophysiological studies of humans with diabetes could be used to assess alterations such as dysfunction of ganglion cells and loss of colour and contrast sensitivity. Sensitivity of the full-field ERG is limited, precisely because it reflects the activity of the entire retina. In contrast, mfERG the ability to measure local ERGs in diabetes which would improve objective detection of early functional alterations and assessment of local change over time. Aim: The purpose of this study was to identify local retinal abnormalities in diabetic subjects with and without non-proliferative diabetic retinopathy (NPDR) using the mfERG. Method: This is a cross sectional study of patients who were clinically diagnosed and sent to us by M& J Regional Institute of Ophthalmology, Ahmedabad, India. Subjects were divided into three groups as group A (normal), B (Diabetics without Retinopathy) and C (Diabetics with Retinopathy) on the basis of medical/ocular history, visual acuity and fundus. mfERG was done in all subjects and the responses were analysed using t test. Result: P1 response density was decreased in Group B and Group C subjects as compared to control in Group A. In subjects with diabetic retinopathy the N1 latencies were higher as compared to diabetics - no DR and control group. When compared the mean global P1 implicit time increased from normal to diabetics - no DR group and DR group. Conclusion: The presence of significant local response delays in eyes without clinically evident retinopathy suggests that such mfERG changes may provide a very early indicator of local retinal dysfunction in diabetes. Key Words: Diabetic Retinopathy, mfERG, N1 Latency, P1 Implicit time
