期刊名称：International Journal of Basic & Applied Physiology
印刷版ISSN：2320-172X
出版年度：2013
期号：1453
页码：213-218
出版社：Society of Basic & Applied Physiology
摘要：Background: Multifocal electroretinography (mfERG) based on the m-sequence stimulation technique which allows quick simultaneous recording of many local electroretinograms from the posterior pole. The multifocal ERG is a powerful tool in patients with an affected cone system, especially when defects are localized and therefore not detectable with full field electroretinography. Aim: The purpose of the present study was to investigate and describe differences in regional dysfunction between groups of patients with impaired vision due to diseases affecting predominantly the posterior pole. Method: This is a retrospective study of patient who were clinically diagnosed and sent to us by M&J Regional Institute of Ophthalmology,Ahmedabad, India. 31 patients were divided into 4 groups including Stargardt’s macular dystrophy (SMD), age-related macular degeneration (AMD), cone dystrophy (CD), central retinal vein occlusion (CRVO) and 11 normal subjects were taken as control. mfERG was done in all subjects and the responses were analysed using t test. Result:In patients with SMD or with AMD functional defects were mainly at the foveal region and extended to eccentricity only in advanced cases. A reduction of response amplitude even in the most peripheral ring was found in cone dystrophies and moderately in patients with central retinal vein occlusion. Prolonged implicit times were found in all but in the patients of SMD and they were maximal in patients with CRVO. Conclusion: The multifocal electroretinography provides detailed information of local activity of the cone dominated retina. In most of the patients with maculopathies, the photopic Ganzfeld ERG was normal, so that multifocal ERG can be valuable in diagnosing these diseases. Key Words: Multifocal ERG, Maculopathy; Cone dystrophy; Central vein occlusion
