出版社：Shahid Sadoughi University of Medical Sciences, yazd, Iran
摘要：Background: Aflatoxins are found in the most types of foods such as corn, peanuts, pis-tachio, rice, milk, and etc. These toxins may cause several adverse health effects, notably cancer. The main aim of this study was to evaluate excretion level of aflatoxin M1 (AFM1), as a biomarker of aflatoxin B1 exposure, in urine samples of Iranian population. Also, relationship between diet and urinary excretion of AFM1 has been discussed. Methods: From June to August 2014, this study was carried out among 70 staffs from Faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. From each participant, 72-h dietary recall was asked and recorded. Then, urine samples were collected separately in the sterile plastic falcon and transferred immediately to the labor-atory and stored at -20 °C. AFM1 was assessed in each sample using ELISA procedure. The data were analyzed by Kruskal–Wallis one-way analysis of variance test using SPSS software (16.0). Results: AFM1 was detected in 15 of 70 (21%) urine samples. The mean levels of con-tamination in faculty members and non-faculty members were 0.6 and 1.7 pg/ml, respec-tively. There was a significant difference between the excretion of AFM1 and consump-tion of nuts as well as Iranian traditional confection (p 0.05). Conclusions: Considering adverse health effect, aflatoxin exposure in this Iranian popu-lation should be reduced. So, comprehensive training of the people is one of the most practical and useful methods for reducing aflatoxin health risks
