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  • 标题:The Effects of a Selective CK2 Inhibitor on Anti-glomerular Basement Membrane Glomerulonephritis in Rats
  • 本地全文:下载
  • 作者:Junfeng Shi ; Ning Liu ; Ying Xiao
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:2015
  • 卷号:38
  • 期号:9
  • 页码:1345-1351
  • DOI:10.1248/bpb.b15-00195
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:

    Protein kinase CK2 (“casein kinase II”) is a protein serine/threonine kinase that plays critical roles in biological processes such as cell growth, cell cycle progression, and apoptosis. So far, we have identified that one catalytic isozyme of CK2, CK2α, is over-expressed in the kidney during the progression of glomerulonephritis (GN). Moreover, we have shown that in vivo inhibition of CK2 by administration of CK2 inhibitors was effective in the treatment of experimental GN. Hence the development of potent CK2 inhibitors should be considered in therapeutic strategies for GN. In the present study we identified compound 13, a pyrazine derivative, as a potent CK2 inhibitor. By performing enzyme kinetics analysis in vitro , we characterized the inhibition of compound 13 toward each CK2 catalytic isozyme. Furthermore, in vivo , we demonstrated that compound 13 is effective in attenuating proteinuria, decreasing the enhanced level of blood urea nitrogen and serum creatinine, and ameliorating glomerular crescent formation in an experimental GN rat model. On the other hand, cellular apoptosis was detected in the rat testis following administration of compound 13 . This study provides clues for new strategies for developing applicable compounds into CK2-targeted GN treatments.

  • 关键词:protein kinase CK2; glomerulonephritis (GN); CK2 inhibitor; testicular toxicity
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