To compare the corneal higher-order aberrations (HOAs) of normal young subjects using Galilei™ G4 (Zeimer, Port, Switzerland) and Pentacam® (Oculus Inc., Wetzlar, Germany).

Corneal HOAs were measured using Galilei™ G4 and Pentacam® in 41 healthy individuals (41 eyes). Intraclass correlation coefficients (ICCs) were obtained to evaluate the repeatability of the 2 devices. Differences in HOAs between the 2 instruments were analyzed with a paired t -test and correlations evaluated.

All ICCs measured using Galilei™ G4 and Pentacam® showed more than moderate repeatability (>0.81) except trefoil, tetrafoil, 4th and 5th HOAs. When comparing the measurements obtained with Galilei™ G4 and Pentacam®, total HOAs, spherical aberration (SA), secondary astigmatism and 5th total HOAs were statistically significantly different between the 2 device (all p ≤ 0.001). In addition, Galilei™ G4 and Pentacam® showed discrepancy among all corneal HOAs items. Although the total corneal HOAs and the SA were significantly correlated, other HOA measurements generally exhibited a low correlation.

Corneal HOAs obtained by the 2 instruments cannot be used interchangeably due to their differences and discrepancy although corneal HOAs measured using Galilei™ G4 and Pentacam® showed relatively high repeatability.