摘要：Staphylococcusaureus ( S.aureus ) is a major cause various infections in humans and animalsthroughout the world. The increasing incidence of S. aureus infection,particularly methicillin-resistant Staphylococcus aureus (MRSA) iscomplicated by the antibiotic-resistance phenomenon. Thus, it requires newstrategies to prevent wider scale of its incidence occurring. Preventativemethods against infectious diseases through vaccination can prevent, controland reduce the severity of the disease process. Various methods have been usedin the development of vaccines to prevent S. aureus infections, but nosatisfactory results have been obtained. Recent studies suggests thatmultivalent vaccines based on cell-mediated immunity is expected to providebetter protection against infection. The purpose of this article is tosummarize the challenges of S. aureus infection and the current statusof its potential solution with the development of a multivalent vaccine and toexplain the latest approaches recommended to obtain successful development of S. aureus vaccine by inducing T-cells CD8+, CD4+ and Th17. Seven MRSAIndonesian origin isolates from humans and dairy-cattle were used as candidatevaccines as genotypic characterization had previously been performed (coa, eta,etb, hla, hlb, cap5, cap8, fnbA, fnbB and mecA). Vaccinationcan be performed with live-attenuated or killed-vaccine and could be combinedwith an injection of aCD40 monoclonal-antibodies (mAbs) with the aim toinduce cellular-based active immunity (T CD8+, CD4+ and Th17). These isolatesare expected to be safe vaccine candidates with immunogenic-protectiveproperties based on genetic and antigenic variation to prevent and controlstaphylococcal infections in humans and animals.
