摘要：There is an old Japanese proverb saying, "After rain falls, the ground hardens." This proverb illustrates what has happened to the research field on the importance of sirtuins in the regulation of aging and longevity. The Sir2 (silent information regulator 2) family of protein deacylases, now called sirtuins, have been shown to regulate aging and longevity in diverse model organisms including yeast, worms and flies. However, mice overexpressing Sirt1, the mammalian ortholog of Sir2, in the whole body failed to show life span extension (Herrenz et al. Nat. Commun., 2010, 1:3).
