摘要：Cellular senescence has long been established as a stable and irreversible growth arrest, which plays an important role in tumor suppression and tissue repair. It can be induced by various stimuli, including telomere shortening, oncogene activation and oxidative stress. We recently demonstrated that cell-cell fusion is a previously unidentified trigger for inducing cellular senescence [1]. This work was the first to demonstrate that fusion-induced senescent cells exist within a normally developed placenta, within an area where physiological cell-cell fusion occurs, thereby suggesting that cellular senescence plays a role in embryonic development.
