摘要：Radiotherapy is a cornerstone of cancer care in non- metastatic patients. It has been incorporated into the treatment regimens of major tumor histologies with curative intent, and is broadly applied for almost any tumor type in the metastastic setting to alleviate symptoms. The cytotoxic effects of radiotherapy have primarily been attributed to double strand DNA damage; however, recent evidence suggests that its immunomodulatory effects can contribute to its therapeutic efficacy. This synergistic potential from combining radiotherapy and immunotherapy may have a role in patients with locally advanced or metastatic cancer.
