摘要：Although chemotherapy can offer long-term survival for patients with cancer, recent reports [1] have revealed that it may induce cognitive dysfunction, such as deficits in attention, concentration, executive function, and processing speed. Whereas such chemotherapy- induced cognitive impairment (CICI) is usually less severe and most often transient, it sometimes impairs activities of daily living and quality of life to the point of debilitation. While it has been recognized as a clinically significant issue in patients, little is known about CICI, particularly in older cancer patients to whom chemotherapy has become more commonly proposed. CICI has been particularly studied among middle-aged women undergoing chemotherapy for breast cancer, while only a small number of studies have focused on older patients. Many of the candidate mechanisms for breast cancer chemotherapy-related brain injury overlap significantly with those involved in aging [2].
