摘要：Radiotherapy involves killing of cancer cells with irradiation and is a widely accepted therapeutic method for treating various types of cancers. However, a portion of cancer cells survives even after radiotherapy and leads to the development of recurrent tumors that gives rise to more malignant phenotypes than that before irradiation. We previously reported that any lung cancer cells that survive after irradiation have high invasiveness, which is regulated by several molecules, such as integrin ¦Â1 [1], myosin regulatory light chain (MRLC) [2], epidermal growth factor receptor [3], and filamin B [4]. These molecules play important roles in cell migration. However, the ability of lung cancer cells to survive irradiation and develop aggressive tumors after irradiation is poorly understood.
