摘要：Among all breast cancer molecular subtypes, triple- negative breast cancer (TNBC) presents the poorest prognosis due to the lack of effective therapeutic options. TNBC, characterized by tumors that do not express estrogen receptor (ER), progesterone receptor (PR), or HER-2 genes, represents approximately 10%¨C 20% of invasive breast cancers and has been associated with African-American race, socio-economic-status, younger age at diagnosis, more advanced disease stage, higher grade, high mitotic indices, a family history of breast cancer and BRCA1 mutations [1]. The search for new therapeutic targets represents an increasing interest to treat this type of breast cancer. The establishment of a clinically relevant mouse model of TNBC is essential to identify and validate genes that might be involved in driving the metastatic cascade, the most lethal aspect of breast cancer, and for potentially screening novel drugs. Moreover, different combinatorial treatments can be tested comparing the effectiveness of various more established and novel chemotherapy modalities since new molecular targets are needed to target this aggressive and lethal type of breast cancer.
