摘要：Malignant gliomas, in particular glioblastoma (GBM), are incurable diseases characterised by high inter- and intra-tumor heterogeneity (ITH), diffuse brain infiltration and treatment resistance. Over the last fifteen years, studies at the interface between stem cell biology and cancer research have established the existence of cancer stem-like populations in GBM and other brain tumors (reviewed in [1]). These data have been accompanied by speculation about neural stem cells being the cell of origin of these malignancies. In support of this hypothesis, mouse models studies have repeatedly suggested that GBM can originate from transformed neural stem/precursor cells [2-4]. However, similar evidence in human was still missing.
