摘要：In physiological conditions, Reactive Oxigen Species (ROS) are present in low amounts and their action can be effectively counteracted by the antioxidant system of the cells. However, cancer cells have higher ROS levels as a consequence of their increased metabolic activity, leading to a state of chronic oxidative stress. Increased levels of ROS are indeed involved in tumorigenesis and progression, conferring a growth advantage to malignant cells thanks to the upregulation of pathways stimulating proliferation and maintenance of the tumoral phenotype. In keeping with this point, cancer cells have a well-adapted antioxidant system to balance their increased generation of ROS [1].
