摘要：Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of the endothelial cell-derived tumor Kaposi's sarcoma and of the lymphoproliferative disorders primary effusion lymphoma and multicentric Castleman's disease. The life cycle of KSHV includes a latent and a lytic/productive phase that both contribute to tumorigenic activity. Major threats for infected tumor cells are attacks of the immune system and the induction of endogeneous cell death programs in response to the virus infection. KSHV opposes these threats for example by hiding from the immune attack by entering the latent infection phase where only few genes are expressed and replication is absent or in the productive phase by the downregulation of major histocompatibility complex class I on the surface of infected cells. Moreover, KSHV uses several different strategies to counteract endogenous cell death programs such as apoptosis and necroptosis.
