标题：BENEFICIAL EFFECTS OF COENZYME Q10 SUPPLEMENTATION ON LIPID PROFILE AND INTEREUKIN?6 AND INTERCELLULAR ADHESION MOLECULE?1 REDUCTION, PRELIMINARY RESULTS OF A DOUBLE?BLIND TRIAL IN ACUTE MYOCARDIAL INFARCTION
摘要：Background: The present investigation was aimed to improve the inflammatory factors and lipoproteins concentration in patients with myocardial infarction (MI) by supplementation with coenzyme Q10 (CoQ10). Methods: In a double ? blind, placebo ? controlled study, we measured serum concentrations of one soluble cell adhesion molecules (intercellular adhesion molecule ? 1 [ICAM ? 1]), serum concentration of intereukin ? 6 (IL ? 6) and lipid profiles (high ? density lipoprotein ? cholesterol [HDL ? C], low ? density lipoprotein ? cholesterol [LDL ? C], total cholesterol and triglyceride [TG]) in CoQ10 supplementation group (n = 26) compared with placebo group (n = 26) in hyperlipidemic patients with MI. Fifty ? two patients were randomized to receive 200 mg/day of CoQ10 or placebo for 12 weeks. Results: There were no significant differences for serum LDL ? C, total cholesterol, and TG between two mentioned groups after the intervention. A significant enhancement in serum HDL ? C level was observed between groups after the intervention (55.46 ± 6.87 and 44.07 ± 6.99 mg/dl in CoQ10 and placebo groups, respectively P < 0.001). Concentrations of ICAM ? 1 (415.03 ± 96.89 and 453.38 ± 0.7 ng/dl CoQ10 and placebo groups, respectively, P = 0.001) and IL ? 6 (11 ± 9.57 and 12.55 ± 8.76 pg/ml CoQ10 and placebo groups, respectively P = 0.001) in serum were significantly decreased in CoQ10 group. Conclusions: Supplementation with CoQ10 in hyperlipidemic patients with MI that have statin therapy has beneficial effects on their aspects of health.
