摘要：Allied to an epidemiological study of population of the Senology Unit of Braga's Hospital that have been diagnosed with malignant breast cancer, we describe the progression in time of repeated measurements of tumor marker Carcinoembryonic antigen (CEA). Our main purpose is to describe the progression of this tumor marker as a function of possible risk factors and, hence, to understand how these risk factors in.uences that progression. The response variable, values of CEA, was analyzed making use of longitudinal models, testing for di.erent correlation structures. The same covariates used in a previous survival analysis were considered in the longitudinal model. The reference time used was time from diagnose until death from breast cancer. For diagnostic of the mo dels fitted we have used empirical and theoretical variograms. To evaluate the fixed term of the longitudinal mo del we have tested for a changing point on the e.ect of time on the tumor marker progression. A longitudinal model was also fitted only to the subset of patients that died from breast cancer, using the reference time as time from date of death until blood test.
