In this study, ascorbic acid (AA), chlorophyll a (Chl-a) and chlorophyll b (Chl-b), were assayed for Genotoxicity and antigenotoxicity, using the somatic mutation and recombination test (SMART) on Drosophila melanogaster . This test is based on the principle that the loss of heterozygosis and the corresponding expression of the suitable recessive markers, multiple wing hairs (mwh) and flare-3 (flr ³ ) can lead to the formation of mutant clone cells in growing larvae, which are expressed as mutant spots on the wings of adult flies. Results indicated that there is no significant genotoxic effect of any of the three chemicals tested. In addition, the antigenotoxic activities of these chemicals, against acrolein and malondialdehyde, were also tested. Results indicate that AA, Chl-a, and Chl-b co-treatments were able to abolish the genotoxic effects induced by the acrolein and malondialdehyde. Thus, our results demonstrated that the antigenotoxic potential of the AA, Chl-a, and Chl-b. According to the mechanisms involved in the genotoxicity of acrolein and malondialdehyde, it is suggested that the observed effects can be linked to the antioxidant properties of the selected AA, Chl-a, and Chl-b. These results will contribute to the increase in the database on the antigenotoxic effects of AA, Chl-a, and Chl-b.