期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2014
卷号：21
期号：1
页码：5-10
出版社：Institute of Agricultural Medicine in Lublin
摘要：Objectives. To evaluate sensitization and acute respiratory health effects in inhabitants living in the vicinity of a factoryproducing soy oil.Methods. Two panels of potential responders were created on the basis of a response to a short screening questionnairesent to random samples of 1,000 exposed and 1,000 non-exposed individuals living around the factory and a controlarea. Individuals responding to the questionnaire were invited for a medical evaluation, including a respiratory symptomquestionnaire and skin prick testing, for a panel of common allergens and a soy allergen extract. This resulted in 53 atopicand/or asthmatic inhabitants from the area surrounding the factory and 30 comparable control subjects. In these subjects,morning and evening Peak Expiratory Flow (PEF), respiratory symptoms and medication use were recorded daily during a10-week period in the autumn. At the same time, soy allergen and endotoxin concentrations were determined in airbornedust in the exposed and the control area. The wind direction relative to the location of a subjects’ house and the factorywas used to determine whether an individual was exposed on a particular day.Results. Only few of the atopic subjects were sensitized to soy. PEF showed a decrease, respiratory symptoms andbronchodilator use, an increase among soy sensitized subjects after having been downwind from the factory. Airbornesoy allergen was found more frequently in the area surrounding the factory and levels were higher than in the controlarea. Highest levels were found on the factory premises. Only a weak association was found with wind direction. Airborneendotoxin concentrations did not show a consistent pattern with distance, but levels were clearly higher on the factorypremises.Conclusion. Sensitization to soy allergen was not increased among the population sample living in the vicinity of thefactory. Soy sensitized individuals living in the surroundings of the factory reported more respiratory symptoms, usedbronchodilators more often and had a lower PEF after having been downwind of the factory
