期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2014
卷号：21
期号：1
页码：132-135
出版社：Institute of Agricultural Medicine in Lublin
摘要：Introduction. Our knowledge in the field of cause of deaths in dialysis patients is rapidly expanding, yet we still do notfully understand how renalase regulates the processes of cardiovascular disease developing in end-stage renal disease.Increased sympathetic nerve activity observed in chronic kidney diseases due to raised catecholamines in plasma resultsfrom the absence of renalase. Renalase synthesized and secreted by the kidneys participate in the regulation of sympathetictone and blood pressure. A family of natriuretic peptides has been identified – NT pro-BNP – which seems to be the bestpredictor of clinical outcome and marker of extracellular fluid overload, as well as predicting mortality, irrespective of renalfunction.Objective. The aim of the presented study was to investigate renalase concentration and investigate associations betweenNT-proBNP, as well as analyzed parameters in haemodialysis patients.Materials and method. The study was conducted among residents of the municipality and neighbouring villages inthe province of Lublin, central-eastern Poland. 49 male subjects on haemodialysis, aged 65.3 ± 14.2 years, median timeon haemodialysis: 37.5 months, were included. All study subjects underwent haemodialysis 3 times a week. The meanconcentration of renalase in the entire study population was 126.59 ± 32.63 ng/mL. The circulating levels of NT-proBNPwas 813.64 ± 706.96 pg/mL. A significant inverse correlation was found between NT-proBNP and renalase plasma levels(R = –0.3, P = 0.03).Conclusions. Inverse correlation between NT-proBNP and renalase plasma levels in haemodialysis patients were due toimpaired kidney function, accompanied by increased sympathetic nerve activity, which have an impact on the developmentof hypertension and cardiovascular complications
