期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2014
卷号：21
期号：1
页码：143-147
出版社：Institute of Agricultural Medicine in Lublin
摘要：Introduction and objective. Gestational diabetes mellitus (GDM) is a pregnancy complication which increases the risk formaternal and foetal complications during pregnancy, and also significantly increases the cardiovascular risk for women’shealth in the postpartum. Current literature provides contradictory information on the role of adiponectin (AdipoQ) inthe course of GDM. The aim of the study was to measure AdipoQ concentration in blood of women with GDM and to findcorrelations between this adipokine and clinical and biochemical parameters of the atherogenic risk.Material and methods. The GDM group included 50 women diagnosed with GDM between 24 – 28 weeks of gestation whounderwent routine prenatal tests for GDM in compliance with the guidelines of the Polish Diabetes Association. All patientsunderwent clinical and laboratory evaluation at GDM diagnosis. Laboratory tests included serum AdipoQ concentration,fasting glucose and insulin, OGTT, lipid parameters, C-reactive protein and fibrinogen in serum.Results. The GDM group showed significantly elevated fasting glucose, insulin, HOMA-IR values, total cholesterol, LDLcholesteroland triglicerydes as compared with the control group (p<0.05). The atherogenic index, CRP, fibrinogen in womenwith GDM were significantly higher than in the control group (p<0.05). AdipoQ concentrations did not differ significantlybetween the groups during gestation (p=0.7054). No correlations, except with the neonatal weight (r= – 0.29, p<0.05), werefound between AdipoQ and the studied parameters.Conclusions. Based on the conducted studies, it may be conclude that women with early diagnosed and promptly treatedGDM have a normal adiponectin level, although insulin resistant changes and increased cardiovascular risk in basic metabolicparameters are observed. Moreover, adiponectin does not reflect the atherogenic risk in pregnant women with GDM.
