期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2014
卷号：21
期号：2
页码：412-415
DOI：10.5604/1232-1966.1108615
出版社：Institute of Agricultural Medicine in Lublin
摘要：Objective. Vascular changes are observed in most cases of Alzheimer’s disease (AD). Observations of AD and vasculardisease (VD) allow us to surmise that vascular changes may not only affect cognitive impairment in AD but may also have anegative influence on the neuropsychiatric symptoms which often occur in the course of the disease. The aim of the studywas to evaluate the impact of vascular factors on the neuropsychiatric symptoms in Alzheimer’s Disease.Material and methods. The study included 48 people with a preliminary diagnosis of Alzheimer’s Disease on the basis ofNINCDS/ADRDA criteria. The evaluation of impairments in cognitive functioning was carried out by means of the AlzheimerDisease Assessment Scale – the cognitive part (ADAS – cog), whereas the behavioural and psychological symptoms wereevaluated by means of the Neuropsychiatric Inventory – the version adapted for residents of nursing homes for the elderly(Neuropsychiatric Inventory – Nursing Home Version) (NPI – NH). The score on the Hachinski scale was the basis for dividingthe study participants into two groups – those with a mild vascular component (0–1 points on the Hachinski scale) andthose with a severe vascular component (2–4 points).Results. The analyzed groups did not differ with respect to the intensity of cognitive impairments (ADAS-cog) or age ofthe participants. Scores obtained on the NPI – NH scale as well as some of its elements (depression/dysphoria and anxiety)had a discriminating value.Studies show that vascular factors are a serious risk factor for neuropsychiatric symptoms in AD.Conclusions. Vascular factors in Alzheimer’s Disease influence the presence of neuropsychiatric symptoms. In the courseof angiogenic dementia a greater frequency in depressive disorders was shown. The most visible differences betweenindividuals with a greater and lesser burden of vascular factors was in the realm of depressive and dysphoric disorders
关键词：nursing homes; psychosocial isolation; AIDS dementia complex; sleep disorders; depression
