期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2014
卷号：21
期号：2
页码：445-449
DOI：10.5604/1232-1966.1108622
出版社：Institute of Agricultural Medicine in Lublin
摘要：Introduction and objective. Taking into consideration the common ontogenic origin of prolactin (Prl) and growth hormone(GH), the Prl circadian pattern was analysed in children with different degrees of GH deficiency (GHD).Materials and methods. The analysis comprised 100 short children (31 girls and 69 boys), aged: 10.1±3.51 years. Based onmaximal GH secretion (GHmax) during two stimulating tests multiple hormone deficiency (MPHD), severe isolated GHD(SIGHD), partial isolated GHD (PIGHD) or idiopathic short stature (ISS) were diagnosed. Non-inferential chronobiometry(macroscopic analysis) of the circadian Prl rhythm, based on serum Prl measured every 3 hours during 24 hours, wasperformed. In this analysis, mesor, the area under curve (AUC), peak and trough level, dispersion, mean nocturnal anddiurnal concentration, night/day ratio, amplitude and regression index were estimated.Results. In the study group, the positive correlations between GHmax and Prl concentrations at 02:00 and at 05:00 wereobserved, as well as between GHmax and mesor, amplitude, mean nocturnal concentration, night/day ratio and AUC. Thenocturnal rise of Prl secretion was blunted in 100% MPHD and 50% SIGHD children, whereas in most children with PIGHDand ISS, the circadian Prl rhythm was normal.Conclusions. 1) In short children, the lower the concentration of GH is, the more blunted nocturnal Prl secretion becomes.2) In the majority of MPHD and SIGHD children (but not PIGHD), the circadian Prl rhythm was disturbed; namely, reducednocturnal Prl secretion was noticeable
关键词：prolactin; circadian rhythm; growth hormone deficiency; children
