期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2014
卷号：21
期号：3
页码：479-484
DOI：10.5604/12321966.1120587
出版社：Institute of Agricultural Medicine in Lublin
摘要：Introduction and objective. Swine confinement buildings are known to contain large concentrations of airway irritants,and a number of studies have shown acute inflammatory effects in previously unexposed subjects when introduced to theenvironment in such buildings. However, studies comparing different methods of assessing such reactions are lacking, and itis not known if a measurable response could be found at lower exposure rates. The purpose of this study was to investigateexposure levels in a Norwegian swine confinement building, the airway response to such exposure, and to compare invasiveand non-invasive methods of response measurement.Materials and method. Twelve medical students who were previously unexposed to swine dust stayed in a swineconfinement building in Norway for 4 hours, and underwent measurements before and after the start of exposure. Thesame measurements were also performed beforehand, on the same weekday without exposure, in such a manner that thesubjects were their own controls.Results. The exposure assessment showed considerably lower concentrations of organic dust and endotoxin than earlierstudies. However, small, but significant increases in markers of airway inflammation, were found.Conclusions. Airway response can be measured after lower exposure to airborne irritants in swine confinement buildingsthan previously known. Further research is needed to assess whether this finding can be utilized for preventive purposes
