期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2014
卷号：21
期号：3
页码：585-589
DOI：10.5604/12321966.1120607
出版社：Institute of Agricultural Medicine in Lublin
摘要：Background. The stimuli acting on a person in a high mountain environment (such as hypobaric hypoxia with subsequentreoxygenation, physical exercise) can significantly increase oxidative stress, stimulate erythropoiesis, lead to changes inthe blood count and participate in the development of altitude sickness.Objective. The aim was to investigate changes in haematological parameters, indicators of oxidative stress (malondialdehyde– MDA) and antioxidant defences: catalase (CAT), superoxide dismutase (SOD), and total antioxidant status (TAS) in theplasma of young, healthy people after a 9-day expedition in the Alps.Materials and method. A total of 5 patients (4 men and 1 woman), members of the Wrocław Mountaineering Club, aged24–26 years. Collection of blood samples was carried out immediately before departure and 3 days after the end of exposureto high-altitude conditions. During the expedition, the subjects were exposed to heights: 2,050–4,165 m.a.s.l., and exerciseassociated with climbing.Results. Trekking in the Alps neither caused significant changes in the parameters of red blood cells nor increased the levelof oxidative stress parameters in plasma. CAT activity increased, the ratio of SOD / CAT decreased. There was also a decreasein the total number of leukocytes, mainly monocytes and basophils.Conclusions. 9-day exposure to high-altitude conditions is not a substantial burden for the organism of young, physicallyactive people. The increase in antioxidant capacity is sufficient to stop oxidative processes, which are severe in theseconditions, and to prevent the occurrence of significant oxidative stress. Discontinuation of exposure to allergens and dustpollution clears the airways, which is indicated by the reduction in the number of monocytes and basophils.
