期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2015
卷号：22
期号：1
页码：106-109
DOI：10.5604/12321966.1141378
出版社：Institute of Agricultural Medicine in Lublin
摘要：Introduction. Head and neck cancers are the most common cancers worldwide. It is estimated that approximately 90%of all head and neck cancers are represented by squamous cell carcinoma (SCC). There are many risk factors causing thistype of cancer, including environmental factors and lifestyle choices, such as tobacco smoking or abusing alcohol. Otherimportant risk factor include infectious factors.Objective. The aim of this study was to analyze the prevalence of BK and JC virus infections among patients with oralsquamous cell carcinoma (OSCC).Materials and method. The correlation between BKV infection and OSCC, and correlation between BKV, OSCC, alcoholabuse, tobacco smoking, demographic data, pre-treatment staging, metastases of lymph node evidence, and grading, wasanalyzed. The study group consisted of 92 patients with squamous cell carcinoma (OSCC), 75 males, and 17 females, agedbetween 40 – 87 (average 56.8). All the patients underwent surgery and were not subjected to chemotherapy or radiotherapyprior to treatment. The analyzed samples were collected from paraffin sections.Results. BKV DNA was detected in 18.5% of patients with OSCC. In the control group, BKV DNA was detected in 3.3%. BKVDNA was statistically more frequently detected among patients with squamous carcinoma, compared to the control group(p<0.05).Conclusions. The obtained results suggest that the BKV virus may play an important role in the development of oralsquamous cell carcinoma
