期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2015
卷号：22
期号：1
页码：167-171
DOI：10.5604/12321966.1141389
出版社：Institute of Agricultural Medicine in Lublin
摘要：Introduction. Despite the undeniably positive effect on the quality of life of menopausal women, menopausal hormonetherapy (HT) also has negative side-effects, which include, among others, thromboembolic complications.Objective. To assess the effect of a popular type of this therapy – transdermal HT on platelet hemostasis, which plays asignificant role in intravascular coagulation.Materials and method. The study group consisted of 92 postmenopausal women: 1) group G1 (n=30), treated withtransdermal HT (17β-estradiol 50 μg/day plus NETA 170 μg/day); 2) group G2 (n=31), treated with the above transdermalHT and low dosage of acetylsalicylic acid (ASA); 3) control group P (n=31). All the women qualified for the study had twoor more risk factors for arterial thrombosis, such as: smoking, hypertension, visceral obesity, hypercholesterolaemia,hypertriglyceridaemia, elevated levels of PAI-1, and increased fibrinogen, increased activity of coagulation factor VII.Results. After three months of therapy, in the G1 group there was a decrease in platelet count (p = 0.004) and a decreasein GP IIb/IIIa – a platelet receptor for fibrinogen (p = 0.022). In the G2 group, no changes in the tested parameters wereobserved.Conclusions. 1) Transdermal HT in the form of combined, estrogen-progestogen patches favourably modifies plateletshaemostasis, reversing the adverse effects that occur after menopause. 2) The use of low ASA doses as a thromboprophylaxisin short-term transdermal HT is not necessary
关键词：menopause; transdermal hormone therapy; platelets; GP IIb/IIIa
