期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2015
卷号：22
期号：2
页码：202-207
DOI：10.5604/12321966.1152065
出版社：Institute of Agricultural Medicine in Lublin
摘要：Introduction and objective. Bacillus anthracis is one of biological agents which may be used in bioterrorism attacks.The aim of this study a review of the new treatment possibilities of anthrax, with particular emphasis on the treatment ofpulmonary anthrax.Abbreviated description of the state of knowledge. Pulmonary anthrax, as the most dangerous clinical form of thedisease, is also extremely difficult to treat. Recently, considerable progress in finding new drugs and suitable therapy foranthrax has been achieved, for example, new antibiotics worth to mentioning, levofloxacin, daptomycin, gatifloxacin anddalbavancin. However, alternative therapeutic options should also be considered, among them the antimicrobial peptides,characterized by lack of inducible mechanisms of pathogen resistance. Very promising research considers bacteriophageslytic enzymes against selected bacteria species, including antibiotic-resistant strains.Results. Interesting results were obtained using monoclonal antibodies: raxibacumab, cAb29 or cocktails of antibodies.The application of CpG oligodeoxynucleotides to boost the immune response elicited by Anthrax Vaccine Adsorbedand CMG2 protein complexes, also produced satisfying therapy results. Furthermore, the IFN-α and IFN-β, PA-dominantnegative mutant, human inter-alpha inhibitor proteins and LF inhibitors in combination with ciprofloxacin, also showedvery promising results.Conclusions. Recently, progress has been achieved in inhalation anthrax treatment. The most promising new possibilitiesinclude: new antibiotics, peptides and bacteriophages enzymes, monoclonal antibodies, antigen PA mutants, and interalpha inhibitors applications. In the case of the possibility of bioterrorist attacks, the examination of inhalation anthraxtreatment should be intensively continued
