期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2015
卷号：22
期号：2
页码：281-285
DOI：10.5604/12321966.1152081
出版社：Institute of Agricultural Medicine in Lublin
摘要：Numerous researches have been carried out on plants of the Rhodiola species, especially Rhodiola kirilowii (Regel) Maxim.and Rhodiola rosea. Various compounds have been reported to be isolated from R. kirilowii and R. rosea, including cyanogenicglycosides, monoterpene alcohols and their glycosides, aryl glycosides, phenylethanoids, phenylpropanoids and theirglycosides (salidroside and rosavins respectively), as well as flavonoids, flavonlignans, proanthocyanidins and gallic acidderivatives and the latter have free radical scavenging capacity. The benefits claimed for Rhodiola include adapogenic,neuroprotective, anti-depresive anti-tumour and cardioprotective activities. Currently, the adaptogenic activity of Rhodiolacompounds are properties evaluated mainly in human clinical trials. The mechanism of the action of Rhodiola extractsinclude affecting the levels of cortisol and NO by interactions with glucocorticoid receptors directly or via the c-JunN-terminal protein kinase (JNK) pathway. However, the natural populations of R. rosea in Poland are threatened; therefore,the cultivation of R. rosea and alternative species R. kirilowii might be a possible solution for producing these kinds of plantsin Poland in sufficient quantities and quality for pharmaceutical purposes. Lack of proven interaction with other drugs andno confirmed adverse effects during clinical trials encourages further investigation. These herb preparations ought to bestudied extensively to establish their position as potential drugs for a variety of diseases
