标题：Neuromarkers of anxiety and depression in a patient after neuro-ophthalmic surgery of the meningioma – effect of individually-tailored tDCS and neurofeedback
期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2015
卷号：22
期号：4
页码：718-723
DOI：10.5604/12321966.1185783
出版社：Institute of Agricultural Medicine in Lublin
摘要：The aim of the study was to evaluate the effectiveness of individually tailored anodal tDCs/ neurofeedback protocol for thereduction of post-operative depression after a neuroophtalmological operation of the meningioma. The neuromarkers inQuantitative EEG (QEEG) and Event-related potentials (ERPs) were utilized in the construction of protocol and evaluation.Case description. A 45-year-old female after successful neuro-ophthalmic surgery of the meningioma, complained of severepain and anxiety, difficulties with sleeping, attention and memory problems, as well as inability to continue working in hergiven profession. Neuropsychological testing showed lack of cognitive disturbances and post-operative depression. Twoworking hypotheses were tested to find neuromarkers of depression and anxiety. In line with the ‘depression hypothesis’ afrontal alpha asymmetry pattern was found in the patient, and in line with the ‘anxiety’ hypothesis an increased left temporalP1 wave in response to visual stimuli was found in ERPs. A specific alpha asymmetry neurofeedback protocol combinedwith an anodal tDCS was suggested. Twenty sessions of individually-tailored anodal tDCs/ neurofeedback protocol wereperformed. The QEEG frontal asymmetry pattern and the excessive temporal P1 wave were normalized after the intervention.Conclusions. The patient recovered from post-operative depression and returned to work after 20 sessions of the combinedneurofeedback/tDCS protocol. Specific patterns of QEEG and ERPs serve as neuromarkers for constructing the protocol andfor monitoring the results of intervention.
