期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2015
卷号：22
期号：4
页码：736-740
DOI：10.5604/12321966.1185786
出版社：Institute of Agricultural Medicine in Lublin
摘要：The peripartum period and delivery are considered critical for maintaining a balance between the production of free oxygenradicals and functional incompetence of the antioxidant system of a foetus and a neonate.Objective. The aim of the study was to evaluate the oxidoreductive state of mothers and their newborns immediately afterdelivery and in the first few days after birth.Method. Eighty-five mothers and their healthy, term newborns were included into the prospective study. Total antioxidantcapacity (TAC) and thiobarbituric acid reactive substances (TBARS) in maternal placenta and milk, as well as blood and urineof the neonates on the first and third day after birth, were examined.Results. Elevated levels of TBARS were found in maternal placenta and neonatal blood on the third day after birth, but lowconcentrations were observed in maternal milk. On the contrary, total antioxidant status (TAS) showed a declining tendencyin neonatal blood and an increasing tendency in breast milk. Markers of oxidative stress and antioxidant capacity wereindependent of the mode of delivery.Conclusions. Values of oxidative stress markers in mothers and newborns immediately after birth were elevated andincreased further during the first few days of neonatal life. Breast milk was the only nutritional substance with highantioxidant activity. At the same time, TBARS levels in breast milk decreased, which might indicate its protective role inreducing oxidative stress in newborns
关键词：oxidative stress; pregnancy; labor; neonate; breast milk
