期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2015
卷号：22
期号：4
页码：762-7667
DOI：10.5604/12321966.1185790
出版社：Institute of Agricultural Medicine in Lublin
摘要：Introduction.The widespread availability of medication without prescription, so-called over the counter (OTC), and the rapiddevelopment of health consciousness of Poles is associated with broad access to medical information in the mass media.This causes patients to recognize their own disease, cancel doctor’s appointments, and begin self-treatment. This timeand money-saving behavior, often signaled by pain, usually leads to the treatment of symptoms alone, without seekingthe cause of the disease.The aim of the study was to present life-threatening paracetamol poisoning, and the treatment ofacute liver failure.Material and Methods. In 2002–2014, 35 patients were hospitalized due to acute paracetamol poisoning: 17 female and 18male patients aged between 17–59 (mean 32.3 years). Patients were treated in the surgical intensive care unit, where theirparameters of liver and renal function were continuously monitored. If there was no improvement in the liver function,patients underwent albumin dialysis with the Prometheus system and were qualified for liver transplantation (LTx).Results. 26 patients were treated pharmacologically and 7 out of 9 patients who underwent LTx were dialyzed. Overall,11 patients had 26 albumin dialysis in total; 4 patients died – 1 post-transplant and 3 pre-transplant.Conclusions. Paracetamol is the cause of many poisonings resulting from the lack of public awareness about toxic interactionswith alcohol, and suicide attempts. Acetaminophen-induced acute liver failure concerns a small percentage of patients butcan be successfully treated with albumin dialysis, and in extreme cases by liver transplantation
关键词：acute liver failure; liver transplantation; over the counter drugs; acetaminophen poisoning
