摘要：Human hair has three main regions, the medulla, the cortex, and the cuticle. An existing model for the cortex suggests that the α -keratin- based intermediate filaments (IFs) align with the hair’s axis, but are orientationally disordered in-plane. We found that there is a new region in the cortex near the cuticle’s boundary in which the IFs are aligned with the hair’s axis, but additionally, they are orientationally ordered in-plane due to the presence of the cuticle/hair boundary. Further into the cortex, the IF arrangement becomes disordered, eventually losing all in-plane orientation. We also find that in the cuticle, a key diffraction feature is absent, indicating the presence of the β -keratin rather than that of the α -keratin phase. This is direct structural evidence that the cuticle contains β -keratin sheets. This work highlights the importance of using a sub-micron x-ray beam to unravel the structures of poorly ordered, multi-phase systems.
