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  • 标题:Hepatic steatosis depresses alpha-1-antitrypsin levels in human and rat acute pancreatitis
  • 本地全文:下载
  • 作者:Qian Wang ; Jianjun Du ; Pengfei Yu
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2015
  • 卷号:5
  • DOI:10.1038/srep17833
  • 出版社:Springer Nature
  • 摘要:Hepatic steatosis (HS) can exacerbate acute pancreatitis (AP). This study aimed to investigate the relation between α1-antitrypsin (AAT) and acute pancreatitis when patients have HS. Using proteomic profiling, we identified 18 differently expressed proteins pots in the serum of rats with or without HS after surgical establishment of AP. AAT was found to be one of the significantly down-regulated proteins. AAT levels were significantly lower in hepatic steatosis acute pancreatitis (HSAP) than in non-HSAP (NHSAP) (P
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