期刊名称:International Journal of Fundamental and Applied Sciences
印刷版ISSN:2278-1404
出版年度:2014
卷号:3
期号:2
页码:17-21
出版社:BioMedAsia
摘要:Cyperus rotundus L. or Mustaka or Motha is a medicinal herb that grows as a turf grass in the sandy or loamy soils of the tropical and subtropical parts of the world. It belongs to the plant family Cyperaceae. The grass is widely known for its antioxidant, anti-inflammatory, anti diabetic and immune modulating properties. Methodology: The present study explores the antidiabetic potential of a particular compound, '15-Hydroxy-4-oxo-10-pentadecynoic acid lactone'obtained by GCMS study, via a series of docking experiments, and ADMET studies. Results: It unravels the several ligand-target interactions that should possibly contribute to this property, and systematically compares it with the binding energy scores of commercial antidiabetic compounds such as metformin and gliclazide.
关键词:Cyperus rotundus L. 15-Hydroxy-4-oxo-10-pentadecynoic acid lactone; metformin and Gliclazide