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  • 标题:Have we found an Optimal Insertion Site in a Newcastle Disease Virus Vector to Express a Foreign Gene for Vaccine and Gene Therapy Purposes?
  • 本地全文:下载
  • 作者:Qingzhong Yu
  • 期刊名称:British Journal of Virology
  • 电子版ISSN:2055-6128
  • 出版年度:2015
  • 卷号:2
  • 期号:2
  • 页码:15-18
  • 出版社:Smith and Franklin Academic Publishing Coporation
  • 摘要:Different approaches have been used to investigate the most suitable insertion site for optimal expression of a foreign gene without compromising the replication of the Newcastle disease virus. Recently, inserting a green fluorescent protein (GFP) gene upstream from the GE sequences of the viral genes and subsequent quantitative measurements of the GFP fluorescence intensity, we have concluded that the P and M junction region is the optimal insertion site for a high level of foreign gene expression by a NDV vector.
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