Maximum temperature trends and the corresponding heat wave thresholds in the northwestern city of Mexicali, Mexico, were analyzed using historical data from the site. We found that there seems to be an upward trend in temperature in the past decades, along with an increased number of days reaching maximum temperatures considered as heat waves. Despite the difficulty of establishing heat wave parameters, the trends of the analyzed field data clearly show their presence, mainly during July and August. This trend is also supported by the analysis of the number of admissions and casualties registered in hospitals in the city of Mexicali. This work is a warning on the frequency and duration of a very important climate change-related effect capable of jeopardizing the health of the population in the region and requiring more attention by decision makers and stakeholders. It also helps to document observed climate trends, as requested by the Intergovernmental Panel for Climate Change.