With the development of modern society, mental illness has become a high incidence of all illnesses. This paper describes the positive role of sport in the rehabilitation of mental illness played from exercise physiology and psychology. And for the various manifestations of mental illness, introduce a number of specific exercise therapies. Finally, we chose 10 student volunteers as our experiment subjects. After one week of exercise therapy, compared the mental state indexes of before and after motion treatment. The final results showed that exercise therapy can significantly improve the psychological status of college students.