This paper aims to introduce a method for better designing of Distribution Center operation process so as to increase the operation efficiency at lower cost. Considering the current situation of a given Distribution Center, this paper designs the operation process and provides the layout chart based on a given number of equipment, operators and volume of goods, etc. Then the concrete actions included in each process step are analyzed, and the standard operation time of each action is calculated using MOST (Maynard Operations Sequence Technique) method. In the end, appropriate numbers of operators are assigned to each process step to ensure line balance. Proper implementation of the method introduced in this paper will bring benefits to corporations regarding to service quality and competitiveness.